SELPLG Polyclonal Antibody for Human(Homo sapiens) | EIAab.comSELPLG Polyclonal Antibody for Human(Homo sapiens)

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SELPLG (Gene name),

P-selectin glycoprotein ligand 1 (Protein name ), SELPL_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SELPLG;

Protein name:

P-selectin glycoprotein ligand 1(PSGL-1);

Alternative:

Selectin P ligand;

CD:

CD162;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Interaction with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Sulfation on Tyr-51 of PSGL1 is most important for high affinity L-selectin/SELL binding while P-selectin/SELP requires sulfation on Tyr-48. E-selectin/SELE binds with much lower affinity and requires the sLe(x) epitope, but apparantly not tyrosine sulfation. Dimerization appears not to be required for P-selectin/SELP binding. Interacts with SNX20.

Function:

A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

412

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

412:

EGDDLTLHSF | LP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

600738

STRING:

9606.ENSP00000373614

UniGene:

Hs.591014

String:

Q14242

KEGG:

hsa:6404

Uniprot:

Q14242

FOR

ELISA Kit for Human PSGL-1

Cat.:

E9106h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human PSGL-1

Cat.:

E9106m

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MSDS:

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Packing:

96T

CLIA Kit for Human PSGL-1

Cat.:

U9106m

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MSDS:

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Packing:

96T

CLIA Kit for Human PSGL-1

Cat.:

U9106h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human PSGL-1

Cat.:

P9106Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PSGL-1

Cat.:

P9106Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human PSGL-1

Protein for Human PSGL-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Genomic organization and chromosomal localization of the gene encoding human P-selectin glycoprotein ligand."
Veldman G.M. , Bean K.M. , Cumming D.A. , Eddy R.L. , Sait S.N.J. , Shows T.B.
J. Biol. Chem.270:16470-16475(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Placenta.
2.

"Expression cloning of a functional glycoprotein ligand for P-selectin."
Sako D. , Chang X.J. , Barone K.M. , Vachino G. , White H.M. , Shaw G. , Veldman G.M. , Bean K.M. , Ahern T.J. , Furie B. , Cumming D.A. , Larsen G.R.
Cell75:1179-1186(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT 132-GLN--ALA-141 DEL
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS ILE-62 AND 132-GLN--ALA-141 DEL
tissue: Uterus.
4.

SeattleSNPs variation discovery resource
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-62 AND SER-246
5.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT 132-GLN--ALA-141 DEL
tissue: Brain.
7.

"The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine."
Moore K.L. , Eaton S.F. , Lyons D.E. , Lichenstein H.S. , Cummings R.D. , McEver R.P.
J. Biol. Chem.269:23318-23327(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 350-355 AND 390-396;INTERACTION WITH SELP AND SELE;STRUCTURE OF CARBOHYDRATE;SUBUNIT;SIALIC ACID CONTENT
tissue: Neutrophil.
8.

"A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding."
Sako D. , Comess K.M. , Barone K.M. , Camphausen R.T. , Cumming D.A. , Shaw G.D.
Cell83:323-331(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION;INTERACTION WITH SELP;MUTAGENESIS OF 46-TYR--ASP-52
9.

"PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus."
Pouyani T. , Seed B.
Cell83:333-343(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION;INTERACTION WITH SELP;MUTAGENESIS OF TYR-46; TYR-48; TYR-51 AND THR-57
10.

"Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin."
Wilkins P.P. , Moore K.L. , McEver R.P. , Cummings R.D.
J. Biol. Chem.270:22677-22680(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION;INTERACTION WITH SELP
11.

"Structures of the O-glycans on P-selectin glycoprotein ligand-1 from HL-60 cells."
Wilkins P.P. , McEver R.P. , Cummings R.D.
J. Biol. Chem.271:18732-18742(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES
12.

"Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin."
Epperson T.K. , Patel K.D. , McEver R.P. , Cummings R.D.
J. Biol. Chem.275:7839-7853(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELP;DISULFIDE BOND AT CYS-320;MUTAGENESIS OF CYS-320
13.

"Tyrosine sulfation enhances but is not required for PSGL-1 rolling adhesion on P-selectin."
Rodgers S.D. , Camphausen R.T. , Hammer D.A.
Biophys. J.81:2001-2009(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELE AND SELP;SULFATION;FUNCTION
14.

"ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1."
Urzainqui A. , Serrador J.M. , Viedma F. , Yanez-Mo M. , Rodriguez A. , Corbi A.L. , Alonso-Lebrero J.L. , Luque A. , Deckert M. , Vazquez J. , Sanchez-Madrid F.
Immunity17:401-412(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MSN AND SYK
15.

"Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51."
Bernimoulin M.P. , Zeng X.-L. , Abbal C. , Giraud S. , Martinez M. , Michielin O. , Schapira M. , Spertini O.
J. Biol. Chem.278:37-47(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELL;FUNCTION;MUTAGENESIS OF THR-44; TYR-48; TYR-51 AND THR-57
16.

"Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin."
Leppaenen A. , Yago T. , Otto V.I. , McEver R.P. , Cummings R.D.
J. Biol. Chem.278:26391-26400(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELL;SULFATION;GLYCOSYLATION
17.

"SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1."
Schaff U.Y. , Shih H.H. , Lorenz M. , Sako D. , Kriz R. , Milarski K. , Bates B. , Tchernychev B. , Shaw G.D. , Simon S.I.
Eur. J. Immunol.38:550-564(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX20
18.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."
Somers W.S. , Tang J. , Shaw G.D. , Camphausen R.T.
Cell103:467-479(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 42-68 IN COMPLEX WITH SELE AND SELP LECTIN/EGF DOMAINS;SULFATION AT TYR-46; TYR-48 AND TYR-51;GLYCOSYLATION AT THR-57;PYROGLUTAMATE FORMATION AT GLN-42
20.

Somers W.S. , Tang J. , Shaw G.D. , Camphausen R.T.
Cell105:971-971(2001)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM

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